Great question. As long as you are not using the Non profit version of QuickBooks Desktop you should be fine. To set up a new company file, you can just go to File and select New. Unfortunately, I do not have a video tutorial for QuickBooks Desktop setup. However, I have included a link to the QuickBooks Desktop support site.
You should be able to find additional instructions and video tutorials here:
Best wishes for a prosperous 2018,